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LUC Loyola Chicago @ SLU Saint Louis -22.5

Wednesday, March 4, 2026 · Wed, March 4th at 8:00 PM EST
Pick
Saint Louis -24.5
LOSS Final: 65-79
Jump to analysis
Secondary Pick
Under 156.5
WIN

Saint Louis vs. Loyola Chicago — Wednesday, March 4th

The Story

This is a revenge spot for a Saint Louis team that already demolished Loyola Chicago 86-59 just three weeks ago on the road. Now the Billikens bring this matchup back to Chaifetz Arena, where they're a ridiculous 19-1. The 24.5-point spread is massive, but is it massive enough?

Here's the thing — Saint Louis just got embarrassed on the road at Dayton (62-77) and Rhode Island (76-81) in their last two away games. They came home, beat Duquesne 91-76, and now get the worst team in the A-10. This is a program with 26 wins looking to make a statement heading into conference tournament seeding. Loyola is 2-9 on the road and just barely scraped past Richmond at home. On the road, this team crumbles.

The Angles

1. The first meeting tells the whole story. Saint Louis won by 27 on Loyola's floor. At home, where they average significantly better numbers, the margin should widen. Loyola scored just 59 points in that game — their second-lowest output in recent weeks — and Saint Louis' defense suffocated them.

2. Pace and scoring mismatch is real but misleading. Loyola actually averages 74.5 PPG on the season, but look closer — on the road against quality opponents, they're routinely held to the low 60s (61 at St. Joe's, 59 vs. SLU, 64 at Davidson). Saint Louis at home has hit 82, 88, and 91 in their last three home wins. The Billikens have five players averaging 13.9+ PPG with elite balance, and Tommie Liddell shooting 45.4% from three makes this offense nearly impossible to scheme against for a bad team.

3. Total leans Under. Saint Louis plays at a methodical pace (62.7 PPG despite their talent), and Loyola on the road can't crack 65 against anyone decent. Even with SLU potentially pushing 80+, Loyola likely stays in the mid-50s to low-60s. The 156.5 total feels inflated by Loyola's home PPG numbers.

The Pick

I'm taking Saint Louis -24.5 at home. They won by 27 on the road against this team. At home where they're 19-1, with extra rest, and likely locked into tournament prep mode — there's no reason this margin shrinks. Loyola's road offense is anemic, and SLU's depth will grind them into dust in the second half.

The half-point at Fanatics (SLU -24) is worth noting, but I'm comfortable at -24.5 given the first meeting margin.

Confidence: 3 units

Secondary lean: Under 156.5 (-112). Loyola simply can't score on the road against good defenses. If SLU gets up big early, the bench comes in and the pace slows to a crawl.

LUC Loyola Chicago
7-22 Overall
2-9 Away
W-1 Streak
SLU Saint Louis
26-3 Overall
19-1 Home
W-1 Streak
LUC SLU
74.5 PPG 62.7
42.0% FG% 42.8%
30.7% 3PT% 34.2%
38.3 RPG 31.1
11.8 APG 13.3
7.3 SPG 7.1
14 TOPG 12.6
LUC Loyola Chicago
PlayerPPGRPGAPG
Blake Schilb 19.1 5.2 3.9
Paul McMillan 17.0 7.4 1.1
DaJuan Gouard 16.0 3.3 3.2
J.R. Blount 15.1 4.0 2.6
Majak Kou 12.9 4.0 1.3
SLU Saint Louis
PlayerPPGRPGAPG
Reggie Bryant 16.4 3.9 1.9
Kwamain Mitchell 15.9 3.0 3.0
Tommie Liddell 15.4 6.8 2.6
Kevin Lisch 14.9 3.6 3.5
Ian Vouyoukas 13.9 7.4 1.7
LUC Loyola Chicago
OppScore
H Richmond 69-66
A Saint Joseph's 61-75
A Fordham 59-62
H Saint Louis 59-86
A Davidson 64-84
SLU Saint Louis
OppScore
H Duquesne 91-76
A Dayton 62-77
H VCU 88-75
A Rhode Island 76-81
A Loyola Chicago 86-59
Book Spread ML Away ML Home O/U
DraftKings -24.5 156.5
Fanatics -24 2500 -10000 156
BetMGM -24.5 2500 -10000 155.5
Lines are subject to change. Odds pulled 1 month ago.
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